Thesis on comparision between granisetron and ondansetron

Thesis On Comparison Between Granisetron And Ondansetron Pon

Abstract Background Ramosetron is a new selective 5-hydroxytryptamine type 3 5-HT3 receptor antagonist that reportedly has more potent antiemetic effects compared with other 5-HT3 receptor antagonists.

This article has been cited by other articles in PMC. The intravenous 2 mg dosage of granisetron was based on the study by Bhattacharya and Banerjee 2. Leeser J, Lip H. Hence intravenous administration just before induction provides a sufficient postoperative antiemetic effect.

Lung cancer was the most common malignancy in both groups Table 1. While de Wit et al report complete protection following cisplatin-based chemotherapy in two out of seven patients receiving granisetron and none out of six patients receiving ondansetron, the principal difference between the efficacy of ondansetron and granisetron in this study was following cyclophosphamide-based therapy.

Laboratory studies monitoring hematological parameters and blood chemistries including liver function tests were performed within seven days of the start of study drug administration and within eight days following the end of study drug administration.

Granisetron: An Update on its Clinical Use in the Management of Nausea and Vomiting

In any case, I did gather that research is being done, looking for tests and markers to help pinpoint more quickly a medication program which would be successful for people.

Ondansetron thesis on comparison between granisetron and ondansetron pon Ryne Hunt found the answer to a search query thesis on comparison Granisetron Versus Ondansetron — Postoperative nausea and vomiting PONV are common and distressing symptoms after surgery performed under general anaesthesia.

The co-administration of corticosteroids, including dexamethasone, was not permitted. Numerous pharmacological agent, regimens, and techniques were evolved from time to time, but they have limited efficacy due to various side effects.

Granisetron vs Ondansetron

The baseline systemic arterial blood pressure, pulse rate, and SpO2 were recorded followed by after premedication, after induction and then at five min intervals till one hour and then at every 15 min till the end of surgery.

For postoperative pain control, patients were administered fentanyl using i. No potential conflict of interest relevant to this article was reported. There were no significant differences between the groups. Ondansetron prevents postoperative emesis in male outpatients.

It is well appreciated that a number of factors including various insults, chemotherapeutic agents, radiation, etc. Peter Blower for reviewing the drug-drug interaction section of the manuscript.

These results were not statistically significant and comparable to studies reported in the literature 222Dizziness, rashes, allergic reactions, and other adverse effects were not reported in the entire study population.

Patients undergoing gynaecological surgery have been associated with high risk for developing PONV. Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery.

The purpose of this study was to evaluate the efficacy of ramosetron for the prevention of postoperative nausea and vomiting PONV with that of ondansetron or placebo in high-risk patients undergoing gynaecological surgery. The need for rescue antiemetic, episode of postoperative nausea and vomiting, and side effects were observed for 12 hours in the post-anesthesia care unit.

May 20,  · In conclusion, the effective ‘switch’ to granisetron in this study may, therefore, be due to a number of factors, but is likely to be attributable primarily to the longer duration of action of granisetron compared with ondansetron rather than the lack of cross resistance between 5.

Granisetron vs Ondansetron

There were no statistical differences between ondansetron, tropisetron and granisetron groups. This study was designed to compare the effectiveness of granisetron plus dexamethasone with.

Nov 01,  · Perez EA, Hesketh P, Sandbach J et al. Comparison of single-dose oral granisetron versus intravenous ondansetron in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy: a multicenter, double-blind, randomized parallel study.

Objectives. To compare the efficacy of intravenous ondansetron (4 mg, 2 mL) and granisetron (2 mg, 2 mL) for preventing postoperative nausea and vomiting (PONV) in patients during oral and maxillofacial surgical procedures under general anesthesia.

Palonosetron, Ondansetron, and Granisetron for antiemetic prophylaxis of postoperative nausea and vomiting - A comparative evaluation Comparison between groups for postoperative nausea and vomiting score was performed by using the Kruskal Wallis.

After IRB approval we compared the effects of ondansetron and granisetron on the various intervals on ECG in 70 patients undergoing elective surgery for carcinoma breast after written informed consent.

to find out the number of patients needed to find a significant difference between the two drugs.

To detect a QTc change from baseline of.

Thesis on comparision between granisetron and ondansetron
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